Causal associations between circulating metabolites and chronic kidney disease: a Mendelian randomization study.

ABSTRACT:

Background

Circulating metabolites have been associated with cross-sectional renal function in population-based research. Nevertheless, there is currently little proof to support the idea that metabolites either cause or prevent renal function. New treatment targets and ways to screen individuals with impaired renal function will be made possible via an in-depth analysis of the causal relationship between blood metabolites and renal function.

Methods

We assessed the causal relationship between 452 serum metabolites and six renal phenotypes (CKD, rapid progression to CKD [CKDi25], rapid eGFR decline [CKD rapid3], dialysis, estimated glomerular filtration rate, and blood urea nitrogen) using univariate Mendelian randomization, primarily employing the inverse variance we

SUBMITTER: He J 

PROVIDER: S-EPMC12044913 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature