Profiling and cheminformatics bioprospection of curcurbitacin I and momordin Ic from <i>Momordica balsamina</i> on α-amylase and α-glucosidase.

ABSTRACT: Momordica spp. has been traditionally used to manage type 2 diabetes mellitus, but the mechanisms and metabolites remain unclear. This study evaluated the inhibitory potential of Momordica balsamina extracts on α-amylase and α-glucosidase in vitro, identifying cucurbitacin I and momordin Ic via high-performance liquid chromatography-photo diode array, and their inhibitory potential in silico. Ethyl acetate seed extract (14.46 µg/ml) and hexane fruit flesh extract (16.79 µg/ml) exhibited lower IC₅₀ values against α-amylase and α-glucosidase, respectively, compared to acarbose (reference standard). Comparatively, momordin Ic concentrations (36.57-605.98 µg/ml) were higher than cucurbitacin I (17.08-44.34 µg/ml). A 140 ns simulation showed that cucurbita

SUBMITTER: Jaichand V 

PROVIDER: S-EPMC12044915 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature