Global, regional, and national time trends in mortality for breast cancer, 1992-2021: an age-period-cohort analysis for the global burden of disease 2021 study.

ABSTRACT:

Background

Breast cancer remains a major global health concern. This study aims to assess the epidemiological trends of breast cancer, with a focus on mortality rates, primary risk factors, and their associations with age, time period, and birth cohort.

Methods

Mortality data were obtained from the Global Burden of Disease Study 2021. An age-period-cohort model was employed to analyze trends in breast cancer mortality and its primary risk factors.

Results

Globally, breast cancer outcomes remained poor between 1992 and 2021, with an estimated 660925.3 deaths in 2021. Mortality rates declined significantly in high and high-middle socio-demographic index (SDI) countries [-1.56%, 95% CI (-1.7 to -1.43)], [-1.03% (-1.11 to -0.94), respectively], but increases markedly in l

SUBMITTER: Fu M 

PROVIDER: S-EPMC12044940 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature