Ge-SAND: an explainable deep learning-driven framework for disease risk prediction by uncovering complex genetic interactions in parallel.

ABSTRACT:

Background

Accurate genetic risk prediction and understanding the mechanisms underlying complex diseases are essential for effective intervention and precision medicine. However, current methods often struggle to capture the intricate and subtle genetic interactions contributing to disease risk. This challenge may be further exacerbated by the curse of dimensionality when considering large-scale pairwise genetic combinations with limited samples. Overcoming these limitations could transform biomedicine by providing deeper insights into disease mechanisms, moving beyond black-box models and single-locus analyses, and enabling a more comprehensive understanding of cross-disease patterns.

Results

We developed Ge-SAND (Genomic Embedding Self-Attention Neurodynamic Decoder), an e

SUBMITTER: Ye L 

PROVIDER: S-EPMC12044951 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature