DSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche.

ABSTRACT:

Background

Radiation induced hematopoietic failure was the primary cause of death after exposure to a moderate or high dose of whole body irradiation, causing increased challenge for nuclear or radiological treatment, so it is an urgent need to develop radioprotectors for attenuating hematopoietic damage caused by acute radiation syndrome (ARS). Given the excellent therapeutic effects and special benefits of mesenchymal stem cells (MSCs) in radiation damaged hematopoietic stem/progenitor cells (HSPCs) recovery and hematopoietic niche reconstruction, enhancing the hematopoietic niche with the radiotolerance MSCs can be an alternative solution to prevent and attenuate hematopoietic radiation damage, which needs to be studied.

Methods

Here, we constructed MSCs modified with Dam

SUBMITTER: Chen FD 

PROVIDER: S-EPMC12045013 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature