Construction of a novel five programmed cell death-related gene signature as a promising prognostic model for triple negative breast cancer.

ABSTRACT:

Background

Triple negative breast cancer (TNBC) is a more aggressive subtype of breast cancer that usually progresses rapidly, develops drug resistance, metastasis, and relapses, and remains a challenge for clinicians to treat. Programmed cell death (PCD), a conserved mechanism of cell suicide controlled by various pathways, contributed to carcinogenesis and cancer progression. Nevertheless, the prognostic significance of PCD-related genes in TNBC remains largely unclear, and more accurate prognostic models are urgently needed.

Methods

Gene expression profiles and clinical information of TNBC patients were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. Least absolute shrinkage and selection operator (LASSO) and multivariate Cox regre

SUBMITTER: Shao Q 

PROVIDER: S-EPMC12045267 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature