Genetic variations of the <i>SHFL</i> gene associated with hepatitis C virus (HCV) infection in Yunnan population.

ABSTRACT: Hepatitis C virus (HCV) infection led to hepatitis C, and even cirrhosis and hepatocellular carcinoma. The SHFL gene belonged to interferon (IFN)-stimulated genes (ISGs) and was identified to inhibit different viruses, including HCV. Whether genetic variations of the SHFL gene was associated with HCV infection was unclear. We collected 347 HCV patients and 448 general controls to genotype three SNPs in the SHFL gene, and analyzed the association between genotypes of SNPs and HCV infection, biochemical indices and disease progression of HCV patients. The results showed that genotype AT of rs77076061 (P = 0.033, OR = 1.515), AG of rs1979262 (P = 0.001, OR = 2.076), and CT of rs12611087 (P = 0.0002, OR = 1.844) were risk factors for HCV infection in Y

SUBMITTER: Cun M 

PROVIDER: S-EPMC12045275 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature