Association between fetal sex and metabolic syndrome in women aged 40 years and older: the REACTION study.

ABSTRACT:

Introduction

This study aimed to investigate whether fetal sex influences the risk of metabolic syndrome (MetS) in women in China.

Materials and methods

A cohort of 3,758 Chinese women, each having given birth to only one child and aged 40 years or older, was included in the study. Registry data on all pregnancies and miscarriages were collected for each participant. This retrospective cohort study aimed to determine whether fetal sex was associated with metabolic syndrome. MetS was defined as meeting at least three of the following five criteria: impaired insulin metabolism, reduced glucose tolerance, hypertension, dyslipidemia, and large waist circumference.

Results

Among the 3,758 women aged 40 years and older in Luzhou City, 1,018 (27.1%) developed MetS. Mothers w

SUBMITTER: Xie Q 

PROVIDER: S-EPMC12045278 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature