Evaluating the interaction between hemorrhagic transformation and cerebral edema on functional outcome after ischemic stroke.

ABSTRACT:

Background

Hemorrhagic transformation (HT) and cerebral edema (CED) are both major complications following ischemic stroke, but few studies have evaluated their overlap. We evaluated the frequency and predictors of CED/HT overlap and whether their co-occurrence impacts functional outcome more than each in isolation.

Methods

892 stroke patients enrolled in a prospective study had follow-up CT imaging evaluated for HT and CED; the latter was quantified using the ratio of hemispheric CSF volumes (with hemispheric CSF ratio < 0.90 used as the CED threshold). The interaction between HT and CED on functional outcome (using modified Rankin Scale at 3 months) was compared to that for each condition separately.

Results

Among the 275 (31%) who developed HT, 233 (85%) manifested

SUBMITTER: Avula A 

PROVIDER: S-EPMC12045300 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature