Population analysis and immunologic landscape of melanoma in people living with HIV.

ABSTRACT:

Purpose

To dissect the clinical and immunological features of people living with HIV (PLWH) diagnosed with melanoma, who have consistently exhibited worse clinical outcomes than HIV-negative individuals (PLw/oH) with the same cancer.

Experimental design

We analyzed electronic health records from 1,019 PLWH and 373,121 PLw/oH diagnosed with melanoma. Demographic and clinical characteristics were compared. Spatial immune transcriptomics (72 immune-related genes) was performed on melanoma tumor samples (n=11), followed by downstream validation using multiplex immunofluorescence (n=15 PLWH, n=14 PLw/oH).

Results

PLWH were diagnosed with melanoma at a younger age, had a higher representation of Hispanic and Black individuals compared to PLw/oH, and a decreased survival rat

SUBMITTER: Barger LN 

PROVIDER: S-EPMC12045344 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature