Pathologic Response to Immunotherapy is Associated with Survival in Patients Undergoing Delayed Nephrectomy for Metastatic Renal Cell Carcinoma.

ABSTRACT:

Introduction

The role of consolidative nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) patients treated with immune checkpoint inhibitors (ICIs) remains unknown. As patients derive variable benefit from immunotherapy (IO), understanding how treatment response correlates with long-term outcomes could inform patient surgical selection. We thus conducted a retrospective study to evaluate whether radiographic and pathologic tumor responses after immunotherapy are associated with survival in patients undergoing CN at a high-volume academic center.

Methods

We identified mRCC patients treated with at least one IO-containing regimen followed by CN between 2015 and 2024. Radiographic response was assessed using RECIST. Pathologic response was measured using percent residua

SUBMITTER: Khandwala YS 

PROVIDER: S-EPMC12045389 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature