Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks.

ABSTRACT: Large-scale genetic association studies have identified thousands of trait-associated risk loci, establishing the polygenic basis for common complex traits and diseases. Although prior studies suggest that many trait-associated loci are pleiotropic, the extent to which this pleiotropy reflects shared causal variants or confounding by linkage disequilibrium remains poorly characterized. To define a set of candidate loci with potentially pleiotropic associations, we performed genome-wide association study (GWAS) meta-analyses of up to 1,167 clinically relevant traits and diseases across 1,789,365 diverse individuals genetically similar to Admixed American (AMR, N_Max = 60,756), African (AFR, N_Max = 128,361), East Asian (EAS, N_Max = 307,465), European (EUR, N

SUBMITTER: Levin MG 

PROVIDER: S-EPMC12045404 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature