The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood.

ABSTRACT: The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of European ancestry and associates with reduced odds of fracture in adults. We aimed to determine if gSOS was associated with bone health in children. Two observational studies of children were evaluated: (1) children enrolled in the Bone Mineral Density in Childhood Study (BMDCS) with genetic data (N=1,727); and (2) children with genetic data for research at the Children's Hospital of Philadelphia (CHOP; N=10,301). Genetic variants were used to calculate gSOS and genetic ancestry. For the BMDCS, puberty stage, dietary calcium, physical activity and fracture accumulation (none or ≥1 fracture) were self-reported, height and weight were measured and

SUBMITTER: Mitchell JA 

PROVIDER: S-EPMC12045425 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature