Genomic Epidemiology of Healthcare-Associated Respiratory Virus Infections.

ABSTRACT:

Background

Respiratory virus transmission in healthcare settings is not well understood. To investigate the transmission dynamics of common healthcare-associated respiratory virus infections, we performed retrospective whole genome sequencing (WGS) surveillance at one pediatric and two adult teaching hospitals in Pittsburgh, PA.

Methods

From January 2, 2018, to January 4, 2020, nasal swab specimens positive for rhinovirus, influenza, human metapneumovirus (HMPV), or respiratory syncytial virus (RSV) from patients hospitalized for ≥3 days were sequenced on Illumina platform. High-quality genomes were assessed for genetic relatedness using ≤3 single nucleotide polymorphisms (SNPs) cut-off, except for rhinovirus (10 SNPs). Patient health records were reviewed for genetically re

SUBMITTER: Srinivasa VR 

PROVIDER: S-EPMC12045434 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature