Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection.

ABSTRACT:

Background

Zika virus (ZIKV) is a mosquito-borne Flavivirus with a strong affinity for the central nervous system (CNS). After infection, ZIKV can cross the blood-brain barrier (BBB) and reach the CNS, causing potential harm to both adult and developing brains.

Methods

The current study aims to evaluate how dysregulated circadian rhythms can affect brain infection by ZIKV, as biorhythms regulate essential physiological processes and disrupted circadian clock can contribute to the pathogenesis of multiple disorders. Both ZIKV infection and circadian rhythm alterations have been related to the disruption of the BBB integrity by modulating the expression of the tight junction (TJ) proteins, however, the input of circadian misalignment on ZIKV infection has never been studied in

SUBMITTER: Teglas T 

PROVIDER: S-EPMC12045451 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature