Leveraging Metal Complexes for Microsecond Lifetime-Based Chloride Sensing.

ABSTRACT: Chloride is the most abundant anion in cells and plays many critical roles in maintaining cellular homeostasis. However, current chloride indicators are rare with inherent sensitivity in their emission properties, such as vulnerability to pH changes or short emission lifetimes. These limitations restrict their application in aqueous media and imaging. In this work, we employed a transition-metal complex bearing pyridinium as a recognition unit for chloride and studied the phosphorescence emission properties. Iridium(III) complex 1 was synthesized as an alternative chloride-sensitive luminophore. The conjugable design also allows customization for the desired applications. Complex 1 exhibited high sensitivity and selectivity in chloride sensing across different physiological e

SUBMITTER: Morse J 

PROVIDER: S-EPMC12045459 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature