Resting-state EEG predicts cognitive decline in a neuropathologically diagnosed longitudinal community autopsied cohort.

ABSTRACT:

Objective

To assess correlative strengths of quantitative electroencephalography (qEEG) and visual rating scale EEG features on cognitive outcomes in only autopsied cases from the Arizona Study of Neurodegenerative Disorders (AZSAND). We hypothesized that autopsy proven Parkinson Disease will show distinct EEG features from Alzheimer's Disease prior to dementia (mild cognitive impairment).

Background

Cognitive decline is debilitating across neurodegenerative diseases. Resting-state EEG analysis, including spectral power across frequency bins (qEEG), has shown significant associations with neurodegenerative disease classification and cognitive status, with autopsy confirmed diagnosis relatively lacking.

Methods

Biannual EEG was analyzed from autopsied cases in AZSAND w

SUBMITTER: Choi A 

PROVIDER: S-EPMC12045475 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature