MiR-27b-3p modulates liver sinusoidal endothelium dedifferentiation in chronic liver disease.

ABSTRACT:

Background

During chronic liver diseases, LSECs undergo a dedifferentiation process contributing to the development of hepatic microvascular dysfunction. Although microRNAs (miRNAs) have been associated with chronic liver disease, their role as modulators of liver endothelial phenotype is mostly unknown. Therefore, the aim of this study was to analyze miRNAs as regulators of hepatic sinusoidal endothelial dysfunction in chronic liver disease to suggest novel and translatable therapeutic options for cirrhosis.

Methods

Global expression of miRNAs was determined in primary LSECs from healthy and cirrhotic patients (alcohol abuse) and rats (CCl4 inhalation). LSECs were transfected with the mimetic or inhibitor of dysregulated miRNAs or with quantum dot nano-complexes containing

SUBMITTER: Abad-Jorda L 

PROVIDER: S-EPMC12045533 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature