Nanoporous Gold for the Miniaturization of In Vivo Electrochemical Aptamer-Based Sensors.

ABSTRACT: Electrochemical aptamer-based sensors enable real-time molecular measurements in the living body. The spatial resolution of these measurements and ability to perform measurements in targeted locations, however, is limited by the length and width of the device's working electrode. Historically, achieving good signal to noise in the complex, noisy in vivo environment has required working electrode lengths of 3-6 mm. To enable sensor miniaturization, here we have enhanced the signaling current obtained for a sensor of given macroscopic dimensions by increasing its surface area. Specifically, we produced nanoporous gold via an electrochemical alloying/dealloying technique to increase the microscopic surface area of our working electrodes by up to 100-fold. Using this approach, we have miniatur

SUBMITTER: Downs AM 

PROVIDER: S-EPMC12045558 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature