Early-life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon.

ABSTRACT: The African turquoise killifish (Nothobranchius furzeri) is becoming a favorable model for neurobiological research. The combination of a short lifespan and a declining neuroregenerative capacity upon aging makes it ideally suited for research on brain aging and regeneration. A remarkable cellular diversity makes up the young-adult killifish telencephalon, characterized by highly proliferative non-glial progenitors and spatially distinct radial glia subtypes. In contrast to a relatively slow embryonic development, hatching is followed by a period of accelerated growth, in which the brain experiences a period of rapid expansion and maturation. In this study, we quantified the growth progression and maturation of the killifish telencephalon during early post-embryonic development. We discove

SUBMITTER: Zandecki C 

PROVIDER: S-EPMC12045632 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature