3D printing a biocompatible elastomer for modeling muscle regeneration after volumetric muscle loss.

ABSTRACT: Volumetric muscle loss (VML) injuries due to trauma, tumor ablation, or other degenerative muscle diseases are debilitating and currently have limited options for self-repair. Advancements in 3D printing allow for the rapid fabrication of biocompatible scaffolds with designer patterns. However, the materials chosen are often stiff or brittle, which is not optimal for muscle tissue engineering. This study utilized a photopolymerizable biocompatible elastomer - poly (glycerol sebacate) acrylate (PGSA) - to develop an in vitro model of muscle regeneration and proliferation into an acellular scaffold after VML injury. Mechanical properties of the scaffold were tuned by controlling light intensity during the 3D printing process to match the specific tension of skeletal muscle. The effect of bot

SUBMITTER: Kiratitanaporn W 

PROVIDER: S-EPMC12045644 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature