Effect of botulinum toxin type A on masticatory function and musculoskeletal structure in rabbits.

ABSTRACT: Botulinum toxin (BTX) injection could relieve many disorders in the maxillofacial regions. Although it could have some side effects on bones and muscles. This study investigated the effects of a single Botulinum Toxin Type A (BoNT-A) injection on masticatory function and musculoskeletal structure in rabbits. Twenty rabbits were divided into two groups: one received BoNT-A (10 units), and the other received saline. The study periodically monitored electromyography (EMG), compound action potential (CAP), food intake, and body weight, along with histological and immunohistochemical analyses after four weeks. Revealed significant reductions in body weight, EMG, and CAP in the BoNT-A group during the first two weeks, but no notable differences in the following two weeks. Histological examinatio

SUBMITTER: Montaser MMS 

PROVIDER: S-EPMC12045985 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature