Is it justified to offer intrauterine infusion of autologous PRP in women with repeated implantation failure?

ABSTRACT: In recent years, an increased interest in the efficacy of intrauterine infusion of autologous platelet-rich plasma (PRP) in women with repeated implantation failure (RIF) has resulted in the publication of 13 randomized controlled trials (RCTs) and 11 meta-analyses. Although these meta-analyses support an increase in pregnancy rates after intrauterine infusion of autologous PRP, the low quality of the available original clinical studies along with concerns regarding their trustworthiness seriously questions their internal validity and does not allow for definitive conclusions to be drawn. In addition, the variability in the definition of RIF used in the individual studies limits their external validity, renders the pooling of the results problematic, and, overall, complicates the extrapola

SUBMITTER: Katsika ET 

PROVIDER: S-EPMC12046075 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature