Mosaic loss of Y chromosome and mortality after coronary angiography.

ABSTRACT:

Background and aims

Acquired somatic mutations emerged as important drivers of adverse cardiovascular disease outcomes. Recently, mosaic loss of Y chromosome (LOY) in haematopoietic cells was identified to induce diffuse cardiac fibrosis in male mice. The aim of the present study was to determine the association between LOY and cardiovascular mortality in patients undergoing coronary angiography.

Methods

LOY was quantified in 1698 male participants of the LURIC study, who underwent coronary angiography, and its association with all-cause and cardiovascular mortality was determined. Furthermore, the interaction between LOY and inherited genetic susceptibility for cardiac fibrosis was assessed.

Results

The frequency of LOY steeply increased in male participants of LURIC

SUBMITTER: Weyrich M 

PROVIDER: S-EPMC12046225 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature