Exposures from Oil and Gas Development and Childhood Leukemia Risk in Colorado: A Population-Based Case-Control Study.

ABSTRACT:

Background

Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphoblastic leukemia (ALL).

Methods

We conducted a case-control study of children born in Colorado between 1992 and 2019. We matched 451 children diagnosed with ALL at ages 2 to 9 years starting in 2002 to 2,706 controls based on birth month/year and Hispanic ethnicity. We estimated upstream O&G activity intensities from conception through a 10-year latency using our intensity-adjusted inverse distance weighted (IA-IDW) model. We applied logistic regression models adjusted for confounders to evaluate associations between ALL and IA-IDW.

Results

For children within 5 km of an O&G well site, we observed a 62% [OR = 1.62; 95% confidence i

SUBMITTER: McKenzie LM 

PROVIDER: S-EPMC12046330 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature