Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.

ABSTRACT:

Significance

This study reveals a broad convergence in genetic adaptation to hypoxia between natural populations and tumors, suggesting that insights from natural populations could enhance our understanding of cancer biology and identify novel therapeutic targets. See related commentary by Lee, p. 875.

SUBMITTER: Arenillas C 

PROVIDER: S-EPMC12046333 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature