Population pharmacokinetic model of oral minocycline in critically ill adult patients with ventilator-associated pneumonia.

ABSTRACT:

Objectives

Multidrug-resistant Acinetobacter baumannii (MDR-A. baumannii) has become an emerging pathogen, causing ventilator-associated pneumonia (VAP), with limited treatment options available. MIN has re-emerged as a potential treatment option for MDR pathogens. However, evidence regarding MIN pharmacokinetic properties in critically ill patients is scarce and primarily limited to IV administration. To address the knowledge gap in regions where IV MIN is unavailable, a prospective, open-label study was conducted to describe the pharmacokinetic properties of orally administered MIN.

Methods

The study included 24 critically ill patients with MDR-A. baumannii VAP. A population PK (popPK) model was developed and the PTA for different MICs was assessed by Monte Carlo simulatio

SUBMITTER: Athanassa Z 

PROVIDER: S-EPMC12046389 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature