Association between prescribed stimulant medications and overdose among individuals receiving opioid agonist therapy: A retrospective cohort study from British Columbia, Canada.

ABSTRACT:

Aims

We measured the association between prescribed stimulant medications and overdose among individuals receiving opioid agonist therapy (OAT) for opioid use disorder.

Design

Retrospective cohort study using the British Columbia Provincial Overdose Cohort, a linked administrative database.

Setting

We used data from British Columbia, Canada, from January 2015 through February 2020.

Participants

In total, 9395 individuals contributed 18 273 person-years of follow-up while dispensed OAT.

Measurements

We examined the association between stimulant prescription (primary exposure) and fatal or non-fatal overdose (primary outcome, allowing for recurrent events) after adjusting for potential confounders including sociodemographic characteristics and substance us

SUBMITTER: Young S 

PROVIDER: S-EPMC12046455 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature