Risk of bleeding with the concurrent use of amiodarone and DOACs: a systematic review and meta-analysis.

ABSTRACT:

Background and aims

Amiodarone is frequently prescribed alongside direct oral anticoagulants (DOACs) in atrial fibrillation. There are concerns regarding drug-drug interactions (DDIs) between amiodarone and DOACs. The literature is conflicting on the clinical implications of this DDI, hence we conducted a meta-analysis to compare bleeding risk among patients receiving DOACs, with and without concurrent amiodarone.

Methods and results

A systematic search was conducted for studies published between 1 January 2009 and 26 June 2024 in MEDLINE via PubMed, Embase, and CENTRAL. Included studies compared major bleeding in patients on concurrent amiodarone and DOACs to those on DOACs without amiodarone. Event rates were used to calculate odds ratios (ORs), which were pooled with a ra

SUBMITTER: Michael F 

PROVIDER: S-EPMC12046584 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature