Probiotic spore-based antigen delivery: a novel oral vaccine strategy against Vibrio infections in aquaculture.

ABSTRACT:

Background

Vibriosis is a deadly illness caused by various species of the Vibrio genus. Due to its high incidence in aquaculture plants, vibriosis is responsible for significant economic losses. Currently, anti-vibriosis treatments rely on antibiotics. However, the global rise in antibiotic resistance necessitates the development of alternative approaches. Novel vaccines and effective probiotics have been proposed as potential alternative to antibiotics in fighting bacterial infections. Here we propose a combined vaccine/probiotic strategy based on the use of probiotic bacterial spores for the oral delivery of Vibrio antigens. Spores of various species of the Bacillus genus are widely used as probiotics and have been shown to efficiently display antigens in a non-recombinant way.

SUBMITTER: De Stefano M 

PROVIDER: S-EPMC12046727 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature