Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy.

ABSTRACT:

Background

Radiation therapy (RT) improves breast cancer outcomes, but cardiac morbidity remains a concern.

Objectives

This study sought to evaluate changes in cardiac function after RT and the relationship between cardiac dose metrics and echocardiography-derived measures of function.

Methods

In a longitudinal cohort study of women with breast cancer, radiation cardiac dose metrics and core lab quantitated echocardiographic measures of cardiac function were evaluated. Dose metrics included the whole heart, left ventricle, right ventricle, and left anterior descending artery (LAD). Echocardiographic measures included left ventricular ejection fraction (LVEF), longitudinal strain, circumferential strain, E/e' (ratio of early diastolic mitral inflow velocity to early di

SUBMITTER: Berlin E 

PROVIDER: S-EPMC12046838 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature