Prognosis, immunological features and potential mechanisms of HKR1 in prostate cancer via single-cell and bulk RNA-sequencing.

ABSTRACT:

Background

Given the limitations of conventional therapies in prostate cancer (PCa) management, identifying novel biomarkers capable of predicting tumor prognosis and immunotherapy response is critically important. This article revealed the prognosis, immunological characteristics, and potential mechanisms of HKR1 in PCa via bulk and single-cell RNA sequencing (scRNA-Seq).

Methods

Bulk and scRNA-Seq analyses of HKR1 in PCa were collected from online databases. Differential expression and Cox regression analyses were carried out to evaluate its expression and prognosis values in PCa, respectively. Correlation analyses were performed to evaluate associations between HKR1 expression and enriched pathways, immune cell infiltration, and other relevant biological processes.

Res

SUBMITTER: Zhai J 

PROVIDER: S-EPMC12046947 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature