<i>Candida albicans</i> isolates contain frequent heterozygous structural variants and transposable elements within genes and centromeres.

ABSTRACT: The human fungal pathogen Candida albicans poses a significant burden on global health, causing high rates of mortality and antifungal drug resistance. C. albicans is a heterozygous diploid organism that reproduces asexually. Structural variants (SVs) are an important source of genomic rearrangement, particularly in species that lack sexual recombination. To comprehensively investigate SVs across clinical isolates of C. albicans, we conducted long-read sequencing and genome-wide SV analysis in three distantly related clinical isolates. Our work includes a new, comprehensive analysis of transposable element (TE) composition, location, and diversity. SVs and TEs are frequently close to coding sequences and many SVs are heterozygous, suggesting that SVs might impact gene

SUBMITTER: Oggenfuss U 

PROVIDER: S-EPMC12047244 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature