Plasma Trough Concentrations of Beta-Lactam Antibiotics in the Early Phase of Septic Shock.

ABSTRACT:

Introduction

Septic shock necessitates timely antibiotic therapy, often with broad-spectrum beta-lactam antibiotics (ß-LA). To our knowledge, no previous study has examined antibiotic concentrations repeatedly during the initial phase of treatment. This observational study aimed to assess early-phase plasma concentrations of ß-LA in patients with septic shock.

Method

Prospective observational study of patients with septic shock, according to the SEPSIS-3 criteria, who received cefotaxime, piperacillin/tazobactam, or meropenem in accordance with Swedish practice. Demographic and clinical data were recorded for each patient. Consecutive blood samples were obtained during the first 24 h of treatment, and total antibiotic concentrations were measured using liquid chromatography

SUBMITTER: Hagglund M 

PROVIDER: S-EPMC12047412 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature