Effects of life history strategies and habitats on limb regeneration in plethodontid salamanders.

ABSTRACT:

Background

Salamanders are the only tetrapods that exhibit the ability to fully regenerate limbs. The axolotl, a neotenic salamander, has become the model organism for regeneration research. Great advances have been made providing a detailed understanding of the morphological and molecular processes involved in limb regeneration. However, it remains largely unknown how limb regeneration varies across salamanders and how factors like variable life histories, ecologies, and limb functions have influenced and shaped regenerative capacities throughout evolution.

Results

This study focuses on six species of plethodontid salamanders representing distinct life histories and habitats. Specimens were examined for regeneration ability after bite injuries as well as after controlled am

SUBMITTER: Bothe V 

PROVIDER: S-EPMC12047434 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature