The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer.

ABSTRACT:

Purpose

Defective DNA damage response (DDR) is a hallmark of cancer leading to genomic instability and is associated with chemosensitivity. Although the mismatch repair system has been extensively studied, the clinical implications of other mechanisms associated with DDR alterations in patients with colorectal cancer remain unclear. This study aimed to understand DDR pathways alterations and their association with common clinical features in patients with colorectal cancer.

Experimental design

Next-generation sequencing and whole-transcriptome sequencing were conducted using formalin-fixed paraffin-embedded samples submitted to a commercial Clinical Laboratory Improvement Amendments-certified laboratory. Samples with pathogenic or presumed pathogenic mutations in 29 specific

SUBMITTER: Arai H 

PROVIDER: S-EPMC12047448 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature