Human Schwann cell exosome treatment attenuates secondary injury mechanisms, histopathological consequences, and behavioral deficits after traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) triggers a series of pathophysiological events, contributing significantly to secondary injury and long-term functional deficits. While exosome therapy is beginning to emerge as a promising avenue for various injuries, its efficacy in TBI, using preclinical models that mimic the biomechanics of human acceleration/deceleration TBI, remains largely unexplored. This study investigated the capacity of human Schwann cell-derived exosomes (hSC-Exo) to improve outcomes in a model of moderate fluid percussion injury (FPI). We found that jugular infusion of hSC-Exo 30 ​min after trauma attenuated acute proinflammatory responses in the ipsilateral cortex and hippocampus 24 ​h post-TBI, as demonstrated by a reduction in levels of key inflammasome components, and decreased

SUBMITTER: Blaya MO 

PROVIDER: S-EPMC12047462 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature