Fluid balance dynamics and early postoperative outcomes in orthotopic liver transplantation: a prospective cohort study.

ABSTRACT:

Introduction

This study evaluates the impact of Fluid Balance (FB) patterns on outcomes after Orthotopic Liver Transplantation (OLT). It hypothesizes that deviations from optimal FB increase morbidity.

Methods

In a single-center cohort post hoc analysis of 73 post-OLT patients, FB was categorized into three groups based on cumulative FB at 72 hours: Lowest (negative FB), Intermediate (0-2000 mL), and Highest (> 2000 mL). We analyzed Sequential Organ Failure Assessment (SOFA) scores, mortality rates, and causes of death. Logistic regression identified mortality predictors.

Results

The Highest FB group had the highest SOFA scores and mortality (Group "Lo": 18.2%, Group "In": 8.6%, Group "Hi": 40.5%, p = 0.009). A U-shaped relationship between FB and hospital mortality w

SUBMITTER: Lobo SM 

PROVIDER: S-EPMC12047465 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature