Nrf2/Bach1 signaling axis: A promising multifaceted therapeutic strategy for Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the most prevalent form of dementia, which continues to elude effective treatment despite decades of research and numerous clinical trials. While existing therapeutic strategies have primarily targeted neuropathological hallmarks such as amyloid plaques and tau tangles, they have failed to halt disease progression, leaving patients with limited options. This persistent failure reveals a critical gap in our understanding of AD and calls for a fresh perspective - one that goes beyond the traditional targets and dives deeper into the fundamental cellular processes that drive neurodegeneration. Recent advances in molecular biology underscore the significance of nuclear factor E2-related factor 2 (Nrf2), often termed the "guardian of redox homeostasis," in the pathop

SUBMITTER: Soni P 

PROVIDER: S-EPMC12047509 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature