BINDER achieves accurate identification of hierarchical TADs by comprehensively characterizing consensus TAD boundaries.

ABSTRACT: As crucial chromatin structures, hierarchical TADs play important roles in epigenetic organization, transcriptional activity, gene regulation, and cell differentiation. Currently, it remains a highly challenging task to accurately identify hierarchical TADs in a computational manner. The key bottleneck for existing TAD callers lies in the difficulty in the prediction of precise TAD boundaries. We solve this problem by introducing a novel algorithm, called BINDER, which conducts a boundary consensus approach, and then precisely locate hierarchical TAD boundaries by developing a multifaceted boundary characterization strategy. In comparison with other leading TAD callers, BINDER shows significant improvement in identifying hierarchical TADs and exhibits the strongest robustness with ultraspa

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12047538 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature