Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.

ABSTRACT:

Background

Vascular smooth muscle cell (VSMC) phenotypic switching contributes to cardiovascular diseases. Epigenetic regulation is emerging as a key regulatory mechanism, with the methylcytosine dioxygenase TET2 acting as a master regulator of smooth muscle cell phenotype. The histone acetyl-transferases p300 and CREB-binding protein (CBP) are highly homologous and often considered to be interchangeable, and their roles in smooth muscle cell phenotypic regulation are not known.

Methods

We assessed the roles of p300 and CBP in human VSMC with knockdown, in inducible smooth muscle-specific knockout mice (inducible knockout [iKO]; p300^iKO or CBP^iKO), and in samples of human intimal hyperplasia.

Results

P300, CBP, and histone acetylati

SUBMITTER: Chakraborty R 

PROVIDER: S-EPMC12047542 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature