Endowing implants surface with enhanced vascularization and osseointegration via presenting triple-functional peptides.

ABSTRACT:

Background

Titanium-based implants have demonstrated good mechanical properties and biocompatibility in clinical applications, however, their inherent low bioactivity and complex biological behaviors during the process of osseointegration have resulted in a high rate of long-term implant failure. Although the immobilization of highly bioactive peptides on the implant surface is an effective strategy to improve osseointegration, the existing mono- and bifunctional peptide-modified implant surfaces can hardly meet the needs of cell behavior regulation and tissue regeneration during the process of osseointegration, and there is an urgent need for the development of more efficient surface modification technologies.

Methods

In the present study, a multifunctional peptide-modified

SUBMITTER: Liu W 

PROVIDER: S-EPMC12047590 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature