Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate.

ABSTRACT: The manipulation of DNA replication and transcription can be harnessed to control cell fate. Central to the regulation of these DNA-templated processes are histone chaperones, which in turn are emerging as cell fate regulators. Histone chaperones are a group of proteins with diverse functions that are primarily involved in escorting histones to assemble nucleosomes and maintain the chromatin landscape. Whether distinct histone chaperone pathways control cell fate and whether they function using related mechanisms remain unclear. To address this, we performed a screen to assess the requirement of diverse histone chaperones in the self-renewal of hematopoietic stem and progenitor cells. Remarkably, all candidates were required to maintain cell fate to differing extents, with no clear correla

SUBMITTER: Franklin R 

PROVIDER: S-EPMC12047658 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature