Inhibition of cytotoxic fibril formation of α-synuclein and human insulin by Silymarin from the Silybum marianum.

ABSTRACT: Silymarin (SIL), the extract obtained from the seeds of milk thistle (Silybum marianum), contains several flavonolignans with a broad range of therapeutic properties such as antioxidant, anti-inflammatory, and neuroprotective effects. Despite several studies indicating the neuroprotective effects of SIL in relating to neurodegenerative diseases (NDs), there is no report regarding the anti-amyloidogenic activity and the mechanism of action of SIL in vitro. Here, we have extracted SIL from the seeds of milk thistle (SIL A), followed by investigating its potential, in comparison with SIL purchased from Sigma company (SIL B), in modulating fibrillogenesis and cytotoxicity of human insulin and α-synuclein (α-syn) amyloid fibrils. The obtained results indicated the potency of both SIL A and SIL

SUBMITTER: Moosakhani B 

PROVIDER: S-EPMC12047757 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature