Extracellular vesicles therapy alleviates cisplatin-ınduced testicular tissue toxicity in a rat model.

ABSTRACT:

Purpose

Cisplatin is a commonly used chemotherapy agent effective against various cancers, however it induces significant gonadotoxicity and infertility due to its adverse effects on testicular function. The underlying mechanisms of cisplatin-induced testicular damage include oxidative stress and dysregulated autophagy. This study investigates the potential of extracellular vesicles (EVs) to mitigate cisplatin-induced testicular damage through their regenerative, antioxidant, and autophagy-modulating properties.

Methods

In the testicular toxicity model, thirty-two male rats were randomly divided into four groups (n = 8): control, EVs-only, Cis-only, and Cis + EVs. A single intraperitoneal dose of 7.5mg/kg cisplatin was administered on the first day. On the six day, the EVs t

SUBMITTER: Tozak Yıldız H 

PROVIDER: S-EPMC12047789 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature