Anatomical and Molecular Characterization of the Zebrafish Meninges.

ABSTRACT: The meninges are a set of connective tissue layers that surround the central nervous system, protecting the brain from mechanical shock, supporting its buoyancy, guarding it from infection and injury, and maintaining brain homeostasis. Despite their critical role, the molecular identity, developmental origins, and functional properties of the cell types populating the meninges remain poorly characterized. This is in large part due to lack of cell type specific markers and difficulty in visualizing and studying these structures through the thick mammalian skull. Here, we show that the zebrafish, a genetically and experimentally accessible vertebrate, possesses an easily imaged mammalian-like meninges. Anatomical and cellular characterization of its composition via histology, electron micros

SUBMITTER: Galanternik MV 

PROVIDER: S-EPMC12047863 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature