<i>APOL1</i> genotype and patient outcomes in US and South African transplant recipients with HIV who received kidneys from donors with HIV.

ABSTRACT:

Importance

Lower kidney allograft survival has been demonstrated in kidney transplant recipients (KTR) without HIV whose donors have two apolipoprotein L1 (APOL1) renal risk variants (RRV). The effects of APOL1 RRV on kidney transplant outcomes in people with HIV (PWH) have not been fully assessed.

Objective

To determine whether APOL1 renal risk variants (G1/G2) in donors or recipients are associated with outcomes of kidney transplantation in people with HIV (PWH)?

Design

Comparative analysis of kidney allograft outcomes in two of the largest longitudinal clinical studies examining transplantation outcomes in PWH.

Setting and participants

Two cohorts of HIV-positive KTR (R+) and their respective HIV-negative (D-) or HIV-positive (D+) kidney

SUBMITTER: Freercks R 

PROVIDER: S-EPMC12047941 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature