Cell type-specific methylome-wide association studies of childhood ADHD symptoms.

ABSTRACT:

Objective

Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical deconvolution to identify cell type-specific DNAm profiles, from five major blood cell types, associated with childhood ADHD symptoms.

Methods

We performed meta-analyses of methylome-wide association studies (MWAS) for ADHD symptoms (age_range=4-16 years) in peripheral blood collected during childhood and in cord blood. The investigated cohorts included seven array-based methylation datasets assaying up to 450K CpGs from the Pregnancy And Childhood Epigenetics Consortium (N=2 934 peripheral blood; N=2 546 cord blood) and a sequenci

SUBMITTER: Meijer M 

PROVIDER: S-EPMC12047943 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature