Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness.

ABSTRACT: Carotid artery intima-media thickness (cIMT) is a measurement of subclinical atherosclerosis that predicts future cardiovascular events, including stroke and myocardial infarction. Genome-wide association studies (GWAS) have identified only a fraction of the genetic variants associated with cIMT. We performed the largest GWAS for cIMT involving up to 131,000 individuals. For the first time, we meta-analysed a diverse range of ancestries including populations with African, Asian (Chinese), Brazilian, European, and Hispanic ancestries. Our study identified 59 independent loci (53 loci from the multi-ancestry single variant analysis of which 19 are novel, P<5×10^-8; 6 novel in gene-based analysis from single variant analysis, P=2.6×10^-6, 2 novel in meta-regression) associ

SUBMITTER: Meena D 

PROVIDER: S-EPMC12047956 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature