The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.

ABSTRACT: Glucocorticoid-producing cells of the adrenal cortex (i.e. zona fasciculata, zF) constitute the critical effectors of the hypothalamic-pituitary-adrenal axis, mediating the mammalian stress response. With glucocorticoids being essential for life, it is not surprising that zF dysfunction perturbs multiple organs that participate in optimizing cardiometabolic fitness. The zF forms a dynamic and heterogenous cell population endowed with the capacity to remodel through the engagement of both proliferative and differentiation programs that enable the adrenal to adapt and respond to diverse stressors. However, the mechanisms that sustain such differential responsiveness remain poorly understood. In this study, we resolved the transcriptome of the steroidogenic lineage by scRNA-seq using <

SUBMITTER: Dumontet T 

PROVIDER: S-EPMC12047992 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature